Professors Manjari Mahajan (New School) and Andrew Lakoff (USC) organised an exciting panel on the changing forms of expertise and knowledge associated with contemporary global health at the Annual Meeting of the Society for Social Studies of Science in Denver in November 2015. The well-attended panel examined emerging techniques and technologies of knowledge production, shifting understandings of what counts as evidence and data, and altering frameworks and infrastructures for measurement and classification. It explored how these new ways of doing science and governance are leading to changed understandings of health and well being and new ways of thinking about the global and about doing good. The panelists included: Prof. Manjari Mahajan, speaking on Making Global Health: the Gates Foundation in India; Dr Alexis Walker (Cornell), speaking on Valuing Life at the World Bank: Costs, Benefits and the Multiplicity of Economic Thought; Dr David Reubi (King’s College London), speaking on Epidemiological Reason: Biopolitics, Surveillance and Global Health; and Prof. Richard Rottenburg (University of Halle), speaking on What is New About Current Trends in Evidentiary Practices?. Professor Andrew Lakoff acted as discussant.